Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1)

Evaluation of the CD123 Expression and FLT3 Gene Mutations in Patients with Acute Myeloid Leukemia

Background and Objective: Identification of cytogenetic and molecular changes plays an important role in acute myeloid leukemia (AML) patients. Thus, they are used in classification, prognosis and treatment of the disease. The CD123 expression and FLT3 gene mutations are also the variations that may assist in prognosis and treatment of patients with AML.Methods:</...

Detection of R882 Mutations in DNMT3A Gene in Acute Myeloid Leukemia: A Method Comparison Study

Background: Somatic mutations in the hotspot region of the DNA-methyltransferase 3A (DNMT3A) gene were recurrently identified in acute myeloid leukemia (AML). It is believed that DNMT3A mutations confer an adverse prognosis for AML patients. These lines of evidence support the need for a rapid and cost-efficient method for the detection of these mutations. The present study aimed to establish h...

DNMT3A Mutations in Acute Myeloid Leukemia

Timothy J. Ley, M.D., Li Ding, Ph.D., Matthew J. Walter, M.D., Michael D. McLellan, B.S., Tamara Lamprecht, B.S., David E. Larson, Ph.D., Cyriac Kandoth, Ph.D., Jacqueline E. Payton, M.D., Ph.D., Jack Baty, B.A., John Welch, M.D., Ph.D., Christopher C. Harris, B.S., Cheryl F. Lichti, Ph.D., R. Reid Townsend, M.D., Robert S. Fulton, M.S., David J. Dooling, Ph.D., Daniel C. Koboldt, M.S., Heather...

Targeting FLT3 Mutations in Acute Myeloid Leukemia

The FMS-like tyrosine kinase 3 (FLT3) pathway has an important role in cellular proliferation, survival, and differentiation. Acute myeloid leukemia (AML) patients with mutated FLT3 have a large disease burden at presentation and a dismal prognosis. A number of FLT3 inhibitors have been developed over the years. The first-generation inhibitors are largely non-specific, while the second-generati...

RUNX 1 mutations in acute myeloid leukemia